Solving the Ebola Virus Genome and Identifying Possible Diagnosis

If you have ever played the card game Killer Bunnies and your Bunnies in the Bunny circle have died because of the Level 11 Weapon of Ebola Virus you want to read this. Research community is making strides to understand whether the virus is adapting to its host or changing as it spreads through the [...]


Mitochondrial Gold Rush

Mitochondrial genomes can be extracted from Whole Exome Sequencing (WES) data as outlined by this paper in Nature methods by Ernesto Picardi & Graziano Pesole. Tools like Mito Seek are now available that gather mitochondrial read sequences from NGS data and perform high throughput sequence analysis. Availability of mitochondrial genomes is important as genomic variation in mitochondria has [...]

R Line Plots – the easiest fastest plot ever

What you need: Data R Eager Bioinformatician For data I used a file with 7 columns where the first column was a counter and the other columns (2-7) had different values that I would like to compare across using a line plot to visualize the variation in my data points Serves: As many data points [...]

How recent are rare variants?

The Department of Genome Sciences at the University of Washington in Seattle, in a multi-institutional effort sequenced 15,336 genes for the NHLBI sponsored ESP project from a total of 6515 individuals of European American and African American descent.To identify approaches for disease-gene discovery, its important to understand evolutionary history of homosapiens and identify the age [...]

The common story of rare variants..

NGS comes to the aid of researchers to find answers for herited complex traits and diseases, paving a path towards the ‘personalized medicine era’. Whole-exome sequencing (WES) has been deployed for identifying rare variants associated with complex diseases and is providing a philip for further research and insight. Common variants that were identified through Genome [...]

The New Genomes of 2012

From the first large genome (goat's genome) to be sequenced and assembled de novo using whole-genome mapping technology, published almost a week ago to around 1000 rice genomes sequenced at 1x coverage: there's a lot that has happened at the Whole Genome Sequencing level. Roche/454 is still being used and so is Sanger, not everyone [...]

HuGGV Poster – Analyzing Variants in 1000 Human Genome Data

Been sometime since I worked on this poster (almost a semester) but its in here before I get myself to work on these variation results and find some answers. Though its interesting to see the trends of different variation across different chromosomes. I found chromosome 19 to stand out in most comparisons. Need to dig [...]